Tumor Necrosis Factor Receptor-Associated Protein 1 (TRAP1), a member of Hsp90 family gained importance when it was found associated with the cytoplasmic domain of type I Tumor Necrosis Factor Receptor- 1(TNFR1) in a yeast two-hybrid screening system (Song et al., 1995). In an independent study using the same model system, another protein was found to be translocated into the nucleus under heat shock where it was bound with the simian virus 40 T-antigen-binding domain of hypophosphorylated retinoblastoma using its unique LxCxE motif and was named Hsp75 (Chen et al., 1996). However, later sequence analysis showed that both proteins were identical.
Mitesh Shrestha 